Highway Killers tells the story of two friends who rent a car and start killing people who cross their path. The two men, who set out on the road after renting a car, begin robbing shops and gas stations along the highway under the influence of heavy drugs. Meanwhile, the pair, who start killing people who cross their path with a pump-action shotgun, make plans to flee the country via the southern border.

Ce synopsis est en anglais : nous ne l'avons pas encore traduit.