The Chemo Club is a feature film which follows strong willed Lulu (Brümilda van Rensburg) and humble Faith (Lillian Dube) as they embark on a heist to recover their stolen funds from a corrupt retirement pensions boss (Chris Chameleon). As former 1970s comic book heroes, they channel their alter egos in the 1970's, enlisting the help of their former colleague (Tobie Cronje) and a younger media student and comic book enthusiast (Rea Rangaka) to complete their heist and return to their glory days.

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